Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

Political Socialization of International Students: Public-Issue Discourse and Discussion on the College Campus     

Mizuki H. Wyant  Elizabeth H. Hurst  Justin Reedy 《Journal of Intercultural Communication Research》2020,49(4):372-393

ABSTRACT

This study examined international students’ interests in public issues in the U.S. and motivational factors behind their discourse or avoidance of such issues. In-depth interviews with international students revealed that they discuss certain public issues in the U.S. to gain or exchange information and knowledge, because these issues are relevant to themselves and others, or due to the misconceptions that others have about their country. Moreover, international students tend to avoid certain public issues because of the level of their knowledge and lack of interest in such issues and in order to avoid dissonance caused by the public issues.  相似文献   

公共健康视角下的电子竞技发展趋势研究     

闫金 《山东体育科技》2020,(1):11-15

电子竞技(E-sports)已经成为当代发展最快,且最重要的文化现象之一。国家体育总局于2003年将它列为第99个运动项目,又在2011年再次将电子竞技改为正式比赛项目。电子竞技从运动员、观众和经济价值而言,是一个不断发展的产业,而且它将被列入2024年巴黎奥运会。虽然最初主要是年轻男性对电子竞技感兴趣,但电子竞技有可能在更广泛的用户群体中带来健康行为的改变。本文运用文献资料法,对比分析法和逻辑分析法探讨电子竞技在整个生命周期内影响健康行为以及一些主要困境的解决措施。除此之外,电子竞技将有可能帮助于个人改变其体育活动和健康行为。最后考虑到电子竞技的指数增长,对于学者和政策制定者来说,认识到电子竞技带来的机遇是非常重要的。  相似文献   

‘He is the Vagabond that Hath No Habitation in the Lord’: The Representation of Quakerism as Vagrancy in Interregnum England,c. 1650–1660     

David Hitchcock 《Cultural and Social History》2018,15(1):21-37

This article examines the printed representation, and prosecutorial characterisation, of the movements, actions and motivations of early Quakers as vagrant. It argues that the prevalence and power of representing (and subsequently treating) early Quakers as vagrants is an understudied aspect of the social and cultural history of the Society of Friends, particularly in Interregnum England. As evidence, it interrogates a furious pamphlet debate between mid-century religious writers and preachers, who devoted much time and ink to painting Quakers as mendacious vagabonds, and Quaker ‘First Publishers’, who responded at length and in a striking way to these accusations. The article concludes that these images of Quakerism as a form of ‘spiritual vagrancy’ created historically significant echoes in English and Atlantic culture.  相似文献   

用户动机视角下的Altmetrics指标研究     

刘晓娟  王晨琳 《图书情报知识》2020,(3):63-70,96

[目的/意义]从用户动机视角对Altmetrics指标的本质和价值进行分析,使Altmetrics的应用更为科学合理。[研究设计/方法]首先对相关文献中的动机进行组织提炼与规范化表述。在此基础上引入用户行为理论解释和分析用户动机体现的指标价值。再选取Twitter提及量指标,使用内容分析法进行案例研究。[结论/发现]提炼出19种用户动机,其中有6种动机会降低指标应用价值。[创新/价值]探索Altmetrics数据的产生机制,在一定程度上回答了Altmetrics指标可用性问题。  相似文献   

Development of evidence-based,student-learning-oriented rubrics for pre-service science teachers’ pedagogical content knowledge     

Vanessa Kind 《International Journal of Science Education》2019,41(7):911-943

ABSTRACT

This paper offers pedagogical content knowledge (PCK) rubrics, that is, guides providing criteria for grading that are potentially applicable to a range of science topics and levels of teacher experience. Grading criteria applied in the rubrics are based on qualitative analyses of planned topic-specific professional knowledge (TSPK) and content knowledge (CK). Data were collected via three topic-specific vignettes from 239 pre-service science teachers (PSTs) starting a university-based, full-time, one year teacher education programme in England. The statements were analysed for TSPK and CK. PSTs’ statements proposed instructional strategies comprising demonstrations, explanations, illustrations and analogies, classified as Relevant to the science topics, others Irrelevant. Some Relevant strategies missed an aspect that may, if enacted, help students’ learning, so were judged Incomplete. Statements were also analysed for evidence of relevant and correct CK. CK and TSPK statements are aligned into grids, creating PCK rubrics. These demonstrate the precise nature of knowledge likely to lead to instruction that impacts positively on student learning. The rubrics present the possibility of PCK repertoires that contribute clarity and precision to teaching instruction. Although findings cannot be generalised, the methodology offers a strategy for supporting out-of-field teachers, and those seeking instructional strategies to add to existing repertoires.  相似文献   

Reputation in the fifteenth century credit market; some tales from the ecclesiastical courts of York     

Hannah Robb 《Cultural and Social History》2018,15(3):297-313

This article explores the language used to defend reputation in instances of defamation, debt and theft presented before the ecclesiastical courts of the Archbishopric of York in the latter part of the medieval period. Finding a circulating language of trust and household credibility in the court papers, the argument concludes that the commodification of reputation was not a phenomenon brought about by the Reformation but that a reputation mechanism was intrinsic to the medieval market embedded in informal institutions, social norms and cultural dictates and enforced in the courts.  相似文献   

Forging developmental relationships in the Grow Your Own Teacher Program     

Estelle Kamler  Karleen Goubeaud 《Mentoring & Tutoring: Partnership in Learning》2018,26(2):207-225

In the Grow Your Own Teacher (GYOT) program, an initiative developed by a university located on Long Island, New York, and funded by a congressionally-directed grant, a diverse cohort of 11th grade low-income students were financially, academically, and emotionally supported in their goal of becoming math or science teachers in predominantly high needs local school districts. In this article, the formation and solidifying of the developmental relationships, which underscored this intensified mentoring effort, were examined. Throughout the selection and implementation phases of the GYOT program, data were collected from multiple sources from both the secondary and post-secondary levels and analyzed to illuminate the organizational structures, activities, and techniques, the relationship-building elements, which enabled these students to flourish and successfully address personal challenges in acquiring a college degree.  相似文献   

在线健康社区用户个人健康信息管理行为特征研究   总被引：3，自引：1，他引：2  

杨梦晴  朱庆华 《图书情报工作》2020,64(1):105-112

[目的/意义] 旨在对在线健康社区用户的个人健康信息管理行为特征进行分析，并在此基础上，对"平台-PHIM-健康目标"这一模式中的元素之间的关系进行探讨。[方法/过程] 选择患有红斑狼疮的在线健康社区用户作为调查对象。采用聚类方法对个人健康信息管理行为的总体测度水平不同的群体进行识别；利用单因素方差分析（One-way ANOVA）对不同群组进行比较研究。[结果/结论] 将依托在线健康社区进行的个人健康信息管理行为界定为健康信息发现、健康信息互动和健康信息分享。从数据分析结果来看，首先，在线健康社区的红斑狼疮患者在个人健康信息管理行为水平上存在显著的高低差异。第二，用户所感知到的社会支持与其个人健康信息管理水平存在正相关关系。第三，个人健康信息管理与用户健康目标之间存在正相关关系。本研究为在线健康社区完善其服务方式，促进慢性病人个人健康信息管理水平提高提供合理建议。  相似文献   

学习团队协作信息搜索的共享心智模型研究   总被引：1，自引：0，他引：1  

颜端武  张馨月  汤佳丽  苏琼 《图书情报工作》2020,64(8):3-12

[目的/意义] 对协作信息搜索进行深入研究，为专业化协作信息搜索系统平台建设优化等提供启发和借鉴。[方法/过程] 聚焦于学习团队的信息搜索行为，以高校学生为研究样本，以共享心智模型为切入点，采用扎根理论研究方法，探讨协作信息搜索中团队共享心智模型建构过程。[结果/结论] 识别出四大核心环节——个体感知与探索、团队任务解析、团队信息收集和团队信息整合，并理清各环节的认知活动与共享心智模型内容要素。  相似文献